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KMID : 0371620080230020173
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Journal of Wonkwang Medical Science
2008 Volume.23 No. 2 p.173 ~ p.177
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A case of intracerebral hemorrhage due to suspicious long-acting anticoagulant rodenticide intoxication in Korea
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Yang Chung-Yong
Lee Jin-Hoon
Lee Se-Oul
Chong Bok-Hee
Noh Sang-Kyun
Shin Yong-Il
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Abstract
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Spontaneous intracerebral hemorrhage is one-tenth of all strokes and represents relatively high frequency and morbidity. Hypertension is the most common cause of spontaneous intracerebral hemorrhage and other causes are vascular malformation, intracerebral amyloid angiopathy, hemorrhagic infarction, blood diseases and drug abuse. Some peoples have the intoxication of drug such as long-acting anticoagulant of rodenticides, family of cumarin, that inhibit vitamin K₁ 2,3-epoxide reductase, the synthesis of vitamin K₁ and subsequently vitamin K₁ dependent clotting factors Ⅱ, Ⅶ, Ⅸ, and Ⅹ. Finally these make prolonged PT, INR and aPTT, which are prone to trigger bleeding tendency. We report a rare case of intracerebral hemorrhage maybe caused by after frequent intended ingestion of long-acting anticoagulant rodenticide(brodifacoum) for suicide.
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KEYWORD
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Long-acting anticoagulant, Rodenticide, intracerebral hemorrhage, intracranial, hemorrhage, Suicide, Drug ingestion
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